4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

Base Information

Chemical Name:4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride
CAS No.:1148046-93-8
Molecular Formula:C₁₇H₁₇F₂N₃OS*ClH
Molecular Weight:385.865
Hs Code.:

Synonyms:4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

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Chemical Property of 4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

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Technology Process of 4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

There total 2 articles about 4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: tert-butyl 4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidine-1-carboxylate

: 1148046-93-8
4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 3h;

Reference yield:

: 1253189-14-8
2-chloro-1-[5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl]ethanone

: 1148046-93-8
4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 4 h / Reflux

2: hydrogenchloride / methanol / 3 h / 20 °C

With hydrogenchloride; In methanol;

Reference yield: 81.0%

: 1148046-93-8
4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride

: 79-04-9
chloroacetyl chloride

: 1227832-02-1
2-chloro-1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]ethanone

Guidance literature:: 4-[4-[4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl]-2-thiazolyl]piperidine hydrochloride; chloroacetyl chloride; In dichloromethane; at -5 ℃; for 0.5h; Inert atmosphere;

With potassium carbonate; In dichloromethane; water; for 0.5h; Inert atmosphere;