4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

Base Information

Chemical Name:4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one
CAS No.:1352079-05-0
Molecular Formula:C₁₇H₁₇F₄N₃O₂
Molecular Weight:371.334
Hs Code.:

Synonyms:4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

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Chemical Property of 4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

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Technology Process of 4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

There total 6 articles about 4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 614731-55-4
4-[3-(4-fluorophenyl)[1,2,4]oxadiazol-5-yl]piperidine hydrochloride

: 406-93-9
4,4,4-trifluorobutyric acid

: 1352079-05-0
4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

Guidance literature:: 4,4,4-trifluorobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;

4-[3-(4-fluorophenyl)[1,2,4]oxadiazol-5-yl]piperidine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm200825u

Reference yield:

: C₁₈H₂₄FN₃O₄

: 1352079-05-0
4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 120 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

3.2: 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm200825u

Reference yield:

: 22179-78-8
4-fluoro-benzamidoxime

: 1352079-05-0
4,4,4-trifluoro-1-{4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

1.2: 20 °C

2.1: N,N-dimethyl-formamide / 120 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h

4.2: 20 °C

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm200825u