2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide

Base Information

• Chemical Name: 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide
• CAS No.: 1251957-71-7
• Molecular Formula: C₂₃H₂₈N₄O₃
• Molecular Weight: 408.5
• Mol file: 1251957-71-7.mol

Synonyms:2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide

Chemical Property of 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide

There total 20 articles about 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-[4-(2-amino-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide (1251957-84-2) + (-)-(R)-2-Pyridylethylene oxide (73908-30-2,237081-53-7) → 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide (1251957-71-7)

Guidance literature:

In water; at 70 ℃; for 17h;

DOI:10.1021/op1001462

Reference yield:

2-chloro-1-(pyridin-2-yl)ethanone (55484-10-1) → 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide (1251957-71-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; formic acid; triethylamine; N,N-dimethyl-formamide; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide / tert-butyl methyl ether / 12 h / 20 °C

1.2: 0.83 h

2.1: sodium hydroxide / 2-methyltetrahydrofuran / 0.67 h / 20 °C

3.1: water / 17 h / 70 °C

With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triethylamine; N,N-dimethyl-formamide; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; sodium hydroxide; In 2-methyltetrahydrofuran; tert-butyl methyl ether; water; 1.1: Noyori hydrogenation;

DOI:10.1021/op1001462

Reference yield:

C29H42N4O3Si → 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide (1251957-71-7)

Guidance literature:

C₂₉H₄₂N₄O₃Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

With water; sodium hydrogencarbonate; In tetrahydrofuran; for 0.166667h;

DOI:10.1021/op1001462

upstream raw materials:

(R)-2-(1-hydroxy-2-chloroethyl)-pyridine

ethyl [4-(2-amino-2-methylpropyl)phenyl]acetate

tert-butyl [2-(4-bromophenyl)-1,1-dimethylethyl]carbamate

(2R)-2-hydroxy-2-(pyridin-2-yl)ethyl 4-methylbenzenesulfonate