55484-10-1

Basic information

• Product Name: Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI)
• Synonyms: Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI);2-chloro-1-(pyridin-2-yl)ethanone
• CAS NO: 55484-10-1
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58164
• Product Categories: ACETYLHALIDE
• Mol File: 55484-10-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI)(55484-10-1)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI)(55484-10-1)

Safety Data

• Hazardous Substances Data: 55484-10-1(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI) is a chemical compound that is also known as 2-chloro-1-pyridin-2-yl-ethanone. It is a derivative of pyridine and an organic compound with a molecular formula of C7H6ClNO. This chemical is widely used in the production of pharmaceuticals, agrochemicals, and various other organic synthesis processes. It is also known for its potential biological activities and is being studied for its potential use in the development of new drugs. However, it is important to handle this chemical with caution as it may have potential health hazards and requires proper safety measures to be followed during handling and storage.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 556025-75-3 [[2-chloro-1-(2-pyridyl)ethenyl]oxy]tri-isopropylsilane 
• 80673-02-5 2,2,2-trichloro-1-(pyridin-2-yl)ethan-1-ol 
• 1440-61-5 N-chloroacetylmorpholine 
• 109-09-1 2-chloropyridine 
• 1122-62-9 2-acetylpyridine 
• 556025-74-2 [[1-(2-pyridyl)ethenyl]oxy]tri-isopropylsilane 

Downstream Products

• 325963-15-3 (S)-2-(1-hydroxy-2-chloroethyl)-pyridine 
• 769140-90-1 (R)-2-(1-hydroxy-2-chloroethyl)-pyridine 
• 73908-30-2 (-)-(R)-2-Pyridylethylene oxide 
• 1251957-71-7 2-[4-(2-{[(2S)-2-hydroxy-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]-N-(5-methylisoxazol-3-yl)acetamide 
• 566947-81-7 (S)-2-(1-hydroxy-2-N-methylamino-ethyl)-pyridine 
• 556025-53-7 (R)-2-(1-hydroxy-2-N-methylamino-ethyl)-pyridine 

Relevant articles and documents

The synthesis of two potent β-3 adrenergic receptor agonists

This contribution describes the initial preparation of two potent β-3 receptor agonists 1 and 2. Subsequent scale up of these two compounds was required for further evaluation and proceeded via a common key amine intermediate 24. Synthesis of this key intermediate by way of a Ritter reaction was a vital step in the sequence. Enantioselective Noyori hydrogenation reactions gave access to the chiral epoxides necessary to make the target compounds. Chemistry was developed for the selective dehalogenation of the 2-chloropyridyl group in the presence of a sensitive isoxazole unit to provide access to 1.

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

As part of medicinal chemistry efforts we found it necessary to develop general syntheses of highly enantiomerically enriched 1-aryl-2-chloroethanols and 1-aryl-2-methylaminoethanols. A survey of literature methods suggested that a truly general approach had not yet been reported, encouraging us to undertake the development of such a methodology. This study describes the design, development, and reduction to practice of a general synthesis of chiral 1-aryl-2-chloroethanols and the transformation of these entities to highly enantiomerically enriched 1-aryl-2-methylaminoethanols. Of particular importance were observations of the impact of solvent and the method of catalyst preparation on the yield and enantiomerical excess of chlorohydrins prepared via Noyori transfer hydrogenations of aryl-chloromethyl ketones.

Pyridoquinoxaline antivirals

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1, R2 and R3 are as defined in the specification. The compounds are useful for the treatment of viral infections.