4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

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Chemical Name:4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester
CAS No.:103891-59-4
Molecular Formula:C₂₅H₄₀N₄O₄
Molecular Weight:460.617
Hs Code.:

Synonyms:4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

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Chemical Property of 4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

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Technology Process of 4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

There total 8 articles about 4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

: 140135-20-2
4-((S)-6-Benzyloxycarbonylamino-2-{[4-(benzyloxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-hexanoylamino)-benzoic acid isobutyl ester

: 103891-59-4
4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

Guidance literature:: With hydrogen; Pd catalyst; In methanol;
DOI:10.1248/cpb.39.2930

Reference yield:

: 27687-13-4
trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carbonyl chloride

: 103891-59-4
4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

2: 83.4 percent / hydrogen / Pd catalyst / methanol

With hydrogen; triethylamine; Pd catalyst; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2930

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 103891-59-4
4-{(S)-6-Amino-2-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-hexanoylamino}-benzoic acid isobutyl ester

Guidance literature:: Multi-step reaction with 5 steps

2: tetrahydrofuran; dimethylformamide / Ambient temperature

3: 5.6 N HCl/dioxane

4: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

5: 83.4 percent / hydrogen / Pd catalyst / methanol

With hydrogenchloride; hydrogen; triethylamine; Pd catalyst; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2930