2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate
• CAS No.: 1060771-74-5
• Molecular Formula: C₃₁H₂₃NO₈
• Molecular Weight: 537.526
• Mol file: 1060771-74-5.mol

Synonyms:2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate

Chemical Property of 2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate

There total 1 articles about 2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

DL-N-(4-methoxybenzoyl)tyrosine (1055912-80-5) + phenyl chloroformate (1885-14-9) → 2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate (1060771-74-5)

Guidance literature:

With triethylamine; at 20 - 25 ℃;

DOI:10.1039/b805850d

Reference yield: 92.0%

2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate (1060771-74-5) → phenyl 2-(4-methoxyphenyl)-5-oxo-4-(4-(phenoxycarbonyloxy)benzyl)-4,5-dihydrooxazole-4-carboxylate (1055912-82-7)

Guidance literature:

With 3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; In dichloromethane; at 20 - 25 ℃; for 0.25h; chemoselective reaction;

DOI:10.1039/b805850d

Reference yield: 90.0%

2-(4-methoxyphenyl)-4-(4-(phenoxycarbonyloxy)benzyl)oxazolyl-5-yl phenyl carbonate (1060771-74-5) → phenyl (R)-2-(4-methoxyphenyl)-5-oxo-4-((4-phenoxycarbonyloxy)benzyl)-4,5-dihydrooxazole-4-carboxylate (1203507-19-0)

Guidance literature:

With 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; In dichloromethane; at -50 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201102847

upstream raw materials:

DL-N-(4-methoxybenzoyl)tyrosine

phenyl chloroformate

Downstream raw materials:

phenyl 2-(4-methoxyphenyl)-5-oxo-4-(4-(phenoxycarbonyloxy)benzyl)-4,5-dihydrooxazole-4-carboxylate

phenyl (R)-2-(4-methoxyphenyl)-5-oxo-4-((4-phenoxycarbonyloxy)benzyl)-4,5-dihydrooxazole-4-carboxylate