(7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

Base Information

Chemical Name:(7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate
CAS No.:1384126-58-2
Molecular Formula:C₂₃H₂₇F₃N₄O₄
Molecular Weight:480.487
Hs Code.:

Synonyms:(7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

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Chemical Property of (7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

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Technology Process of (7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

There total 4 articles about (7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384126-57-1
tert-butyl ((7S,8R)-8-(2,4,5-trifluorophenynl)-1,2,3,4,6,7,8,9-octahydrobenzo[4,5]imidazo[1 ,2-a]pyrazin-7-yl)carbamate

: 124-41-4
sodium methylate

: 530-62-1
1,1'-carbonyldiimidazole

: 1384126-58-2
(7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

Guidance literature:: tert-butyl ((7S,8R)-8-(2,4,5-trifluorophenynl)-1,2,3,4,6,7,8,9-octahydrobenzo[4,5]imidazo[1 ,2-a]pyrazin-7-yl)carbamate; 1,1'-carbonyldiimidazole; In toluene; at 20 ℃; for 1h;

sodium methylate; In methanol; toluene; at 20 ℃; for 0.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1384126-58-2
(7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 20 °C

3.1: toluene / 1 h / 20 °C

3.2: 0.5 h / 20 °C

With ammonium formate; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 1384126-53-7
(7S,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazin-7-amine

: 1384126-58-2
(7S,8R)-methyl 7-((tert-butoxycarbonyl)amino)-8-(2,4,5-trifluorophenyl)3,4,6,7,8,9-hexahydrobenzo [4,5]imidazo [1,2-a]pyrazine-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 20 °C

3.1: toluene / 1 h / 20 °C

3.2: 0.5 h / 20 °C

With ammonium formate; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene;