3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

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Chemical Name:3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide
CAS No.:1374986-74-9
Molecular Formula:C₂₈H₃₂N₄O₆S
Molecular Weight:552.651
Hs Code.:

Synonyms:3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

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Chemical Property of 3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

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Technology Process of 3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

There total 3 articles about 3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280-13-7
8-oxa-3-aza-bicyclo[3.2.1]octane

: 1374986-74-9
3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 4 h

2: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(I) bromide / 1-methyl-pyrrolidin-2-one / 110 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water / 2 h / Reflux

4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation

With pyridine; 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.008

Reference yield:

: 1374986-85-2
C₁₂H₁₄BrNO₃S

: 1374986-74-9
3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(I) bromide / 1-methyl-pyrrolidin-2-one / 110 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 2 h / Reflux

3: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation

With 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.008

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1374986-74-9
3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 4 h

2: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(I) bromide / 1-methyl-pyrrolidin-2-one / 110 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water / 2 h / Reflux

4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation

With pyridine; 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.008