Bis(2-methoxyphenyl)phenylphosphine

Base Information

• Chemical Name: Bis(2-methoxyphenyl)phenylphosphine
• CAS No.: 36802-41-2
• Molecular Formula: C20H19 O2 P
• Molecular Weight: 322.343
• Hs Code.: 29310099
• DSSTox Substance ID: DTXSID40402923
• Nikkaji Number: J1.355.211H
• Wikidata: Q72446287
• Mol file: 36802-41-2.mol

Synonyms:Bis(2-methoxyphenyl)phenylphosphine;36802-41-2;bis(2-methoxyphenyl)(phenyl)phosphine;bis(2-methoxyphenyl)-phenylphosphane;MFCD00061478;Bis(o-anisyl)phenylphosphine;SCHEMBL476857;DTXSID40402923;MVKZAEARORRRPG-UHFFFAOYSA-N;bis-(2-methoxyphenyl)phenylphosphine;bis(2-methoxyphenyl)(phenyl)phosphane;AKOS015915671;Phosphine, bis(2-methoxyphenyl)phenyl-;CS-0087120;FT-0741127;E75768;BIS-(2-METHOXY-PHENYL)-PHENYL-PHOSPHANE

Chemical Property of Bis(2-methoxyphenyl)phenylphosphine

Chemical Property:

• Melting Point: 158-163 °C(lit.)
• PSA: 32.05000
• LogP: 3.46200
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 322.11226684
• Heavy Atom Count: 23
• Complexity: 319

Purity/Quality:

99% ^*data from raw suppliers

Bis(2-methoxyphenyl)phenylphosphine, min. 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1P(C2=CC=CC=C2)C3=CC=CC=C3OC

Technology Process of Bis(2-methoxyphenyl)phenylphosphine

There total 5 articles about Bis(2-methoxyphenyl)phenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromoanisole (578-57-4) + Dichlorophenylphosphine (644-97-3) → bis-(2-methoxy-phenyl)-phenyl-phosphane (36802-41-2)

Guidance literature:

2-bromoanisole; With n-butyllithium; In diethyl ether; hexane; at -78 - 0 ℃; for 1h; Inert atmosphere; Schlenk technique;

Dichlorophenylphosphine; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.6b00638

Reference yield: 94.0%

methoxybenzene (100-66-3) + Dichlorophenylphosphine (644-97-3) → bis-(2-methoxy-phenyl)-phenyl-phosphane (36802-41-2)

Guidance literature:

methoxybenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at 20 ℃; for 2h;

Dichlorophenylphosphine; In diethyl ether; hexane; for 0.5h;

DOI:10.1016/j.tetasy.2006.03.010

Reference yield:

2-bromoanisole (578-57-4) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → bis-(2-methoxy-phenyl)-phenyl-phosphane (36802-41-2)

Guidance literature:

DOI:10.1021/ja00840a029

upstream raw materials:

methoxybenzene

Dichlorophenylphosphine

2-bromoanisole

chloro-diphenylphosphine

Downstream raw materials:

C₅(CH₃)5IrCl₂(P(C₆H₅)(C₆H₄OCH₃)2)

bis(2-methoxyphenyl)(phenyl)(p-tolylethynyl)phosphonium bromide

bis(2-methoxyphenyl)(phenyl)(o-tolylethynyl)phosphonium bromide

bis(2-methoxyphenyl)(phenyl)((3-(trifluoromethyl)phenyl)ethynyl)phosphonium bromide

Refernces

• 1、 Zhou, Hui,Zhang, Jinlong,Yang, Huameng,Xia, Chungu,Jiang, Gaoxi. "Rhodium-Catalyzed Double Alkyl-Oxygen Bond Cleavage: An Alkyl Transfer Reaction from Bis/Tris(o-alkyloxyphenyl)phosphine to Aryl Acids". supporting information. p. 3406 - 3412. Retrieved 2016/10/21.
• 2、 Jiang, Biao,Huang, Zuo-Gang,Cheng, Ke-Jun. "Preparation of N-phenyl-(S)-prolinol-derived P,N-ligands and their application in Pd-catalyzed asymmetric allylic alkylation". . p. 942 - 951. Retrieved 2007/10/03.