(S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

Base Information

Chemical Name:(S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate
CAS No.:1599440-62-6
Molecular Formula:C₂₈H₄₁NO₇
Molecular Weight:503.636
Hs Code.:

Synonyms:(S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

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Chemical Property of (S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

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Technology Process of (S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

There total 3 articles about (S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 95592-67-9
4-pivaloyloxybenzaldehyde

: 1101108-51-3
tert-butyl N-tert-butoxycarbonyl-N-hex-5-ynyl-carbamate

: 1599440-62-6
(S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

Guidance literature:: tert-butyl N-tert-butoxycarbonyl-N-hex-5-ynyl-carbamate; With (-)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine; In toluene; for 0.333333h; Inert atmosphere;

4-pivaloyloxybenzaldehyde; In toluene; at 20 ℃; Inert atmosphere;
DOI:10.1002/ijch.201300041

Reference yield:

: 76911-01-8
5-hexynyl p-toluenesulfonate

: 1599440-62-6
(S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: zinc trifluoromethanesulfonate; (-)-N-methylephedrine; triethylamine / toluene / 0.33 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With (-)-N-methylephedrine; zinc trifluoromethanesulfonate; sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1002/ijch.201300041

Reference yield:

: 51779-32-9
iminodicarboxylic acid di-tert-butyl ester

: 1599440-62-6
(S)-4-7-(N,N-di-(tert-butyloxycarbonyl)-1-hydroxyhept-2-yn-1-yl)phenyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: zinc trifluoromethanesulfonate; (-)-N-methylephedrine; triethylamine / toluene / 0.33 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With (-)-N-methylephedrine; zinc trifluoromethanesulfonate; sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1002/ijch.201300041