95592-67-9

Basic information

• Product Name: 4-FORMYLPHENYL PIVALATE
• Synonyms: 4-FORMYLPHENYL PIVALATE
• CAS NO: 95592-67-9
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 0
• Mol File: 95592-67-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-FORMYLPHENYL PIVALATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYLPHENYL PIVALATE(95592-67-9)
• EPA Substance Registry System: 4-FORMYLPHENYL PIVALATE(95592-67-9)

Safety Data

• Hazardous Substances Data: 95592-67-9(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1184-88-9 sodium pivalate 
• 100-52-7 benzaldehyde 

Downstream Products

• 144758-74-7 di(4-pivaloyloxybenzyl) methoxycarbonylmethylphosphonate 
• 16174-47-3 1,1-bis(4-hydroxyphenyl)-2-ethylbut-1-ene 
• 865231-46-5 [3H]-AMG 837 
• 1292290-97-1 (S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid ethyl ester 

Relevant articles and documents

Synthesis of multi-substituted 1,2,4-triazoles utilising the ambiphilic reactivity of hydrazones

The synthesis of N-alkyl-1H-1,2,4-triazoles from N,N-dialkylhydrazones and nitriles via formal [3+2] cycloaddition including the C-chlorination/nucleophilic addition/cyclisation/dealkylation sequence was developed. This sequential reaction utilising the in situ generation of hydrazonoyl chloride based on the ambiphilic reactivity of hydrazones afforded a variety of multi-substituted N-alkyl-triazoles in high yields. The synthetic utility of multi-substituted triazoles was also demonstrated by further transformations.

Chemoselective Cross-Coupling between Two Different and Unactivated C(aryl)-O Bonds Enabled by Chromium Catalysis

We report here the first example of cross-coupling between two different and unactivated C(aryl)-O bonds with chromium catalysis. The combination of a low-cost Cr(II) salt, 4,4′-di-tert-butyl-2,2′-dipyridyl (dtbpy) as the ligand, and magnesium as the reductant shows high reactivity in promoting the reductive cross-coupling of aryl methyl ether derivatives with aryl esters by cleavage and coupling of two different C(aryl)-O bonds under mild conditions. The formation of active low-valent Cr species by reduction of CrCl2 with Mg can be considered, which prefers to initially activate the C(aryl)-O bond of phenyl methyl ether with the chelation help of dtbpy and an o-imine auxiliary. The subsequent consecutive reduction, second C(aryl)-O activation, and reductive elimination allow for the achievement of selective cross-coupling of C(aryl)-O/C(aryl)-O bonds.

Method for synthesizing AMG837

The invention relates to a method for synthesizing a compound, in particular to a method for synthesizing AMG837. The method comprises the following steps: a step of preparing an intermediate D by a reaction of an intermediate E with propyne; a step of de