(2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

Base Information

Chemical Name:(2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol
CAS No.:173098-01-6
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:(2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

Suppliers and Price of (2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

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Technology Process of (2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

There total 6 articles about (2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 100-52-7
benzaldehyde

: 173098-00-5
(2S,3S,4R)-3-(benzyloxy)-1-(1H-imidazol-4-yl)butane-1,2,4-triol

: 173098-01-6
(2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

Guidance literature:: With zinc(II) chloride; for 24h; Ambient temperature;
DOI:10.1002/hlca.19950780717

Reference yield:

: 23558-05-6
3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose

: 173098-01-6
(2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / t-BuOK / 1,2-dimethoxy-ethane / 1.5 h

2: 95 percent / Et₃N, POCl₃ / 1,2-dimethoxy-ethane / 1.5 h / -5 °C

3: 66 percent / 20 percent NH₃ / methanol / Ambient temperature

4: 68 percent / 4 percent aq. H₂SO₄ / dioxane / 2 h / Heating

5: 71 percent / NaBH₄ / ethanol / 24 h / Ambient temperature

6: 71 percent / ZnCl₂ / 24 h / Ambient temperature

With ammonium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; triethylamine; zinc(II) chloride; trichlorophosphate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol;
DOI:10.1002/hlca.19950780717

Reference yield:

: 4-<(4'R)-3'-O-benzyl-L-threofuranose-4-C-yl>-1H-imidazole

: 173098-01-6
(2S,3S,4R)-3-benzyl-2,4-(benzylidenedioxy)-4-(1H-imidazol-4-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / NaBH₄ / ethanol / 24 h / Ambient temperature

2: 71 percent / ZnCl₂ / 24 h / Ambient temperature

With sodium tetrahydroborate; zinc(II) chloride; In ethanol;
DOI:10.1002/hlca.19950780717