4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

Base Information

Chemical Name:4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester
CAS No.:119900-56-0
Molecular Formula:C₂₅H₂₇FNO₅P
Molecular Weight:471.465
Hs Code.:

Synonyms:4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

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Chemical Property of 4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

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Technology Process of 4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

There total 6 articles about 4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119899-84-2
C₂₀H₂₀ClFNO₂P

: 105-45-3
acetoacetic acid methyl ester

: 119900-56-0
4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

Guidance literature:: With n-butyllithium; sodium hydride; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jm00173a007

Reference yield:

: 101125-34-2
3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde

: 119900-56-0
4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / -78 °C

2: p-toluenesulfonic acid / benzene / Heating

3: 1 N LiOH / dioxane

4: CH₂Cl₂

5: oxalyl chloride, DMF / CH₂Cl₂

6: NaH_. n-BuLi / tetrahydrofuran / -78 °C

With lithium hydroxide; n-butyllithium; oxalyl dichloride; sodium hydride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm00173a007

Reference yield:

: 119900-54-8
{(E)-2-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-vinyl}-phosphonic acid dimethyl ester

: 119900-56-0
4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]methoxyphosphinyl]-3-oxobutanoic acid, methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1 N LiOH / dioxane

2: CH₂Cl₂

3: oxalyl chloride, DMF / CH₂Cl₂

4: NaH_. n-BuLi / tetrahydrofuran / -78 °C

With lithium hydroxide; n-butyllithium; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00173a007