Technology Process of 1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-[1,2]thiazinane-3-carboxylic acid
There total 8 articles about 1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-[1,2]thiazinane-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dicyclohexyl-carbodiimide / dmap / dichloromethane / 1 h / 20 °C
2.1: hydrogen / palladium on activated charcoal / ethanol / 2 h / 2327.23 Torr
3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -20 °C
3.2: 2 h / Cooling with ice
4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h
4.2: 5 h / 20 °C / Cooling with ice
5.1: sodium acetate; acetic acid / water / 0.17 h / Cooling with ice
6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice
7.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
4-methyl-morpholine; di-isopropyl azodicarboxylate; hydrogen; sodium acetate; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; isobutyl chloroformate;
dmap; palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen / palladium on activated charcoal / ethanol / 2 h / 2327.23 Torr
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -20 °C
2.2: 2 h / Cooling with ice
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h
3.2: 5 h / 20 °C / Cooling with ice
4.1: sodium acetate; acetic acid / water / 0.17 h / Cooling with ice
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice
6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
4-methyl-morpholine; di-isopropyl azodicarboxylate; hydrogen; sodium acetate; potassium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
![1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-[1,2]thiazinane-3-carboxylic acid tert-butyl ester](/Databaselist/images/loading.webp)
