2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester
CAS No.:1310037-42-3
Molecular Formula:C₂₁H₃₁NO₆
Molecular Weight:393.48
Hs Code.:

Synonyms:2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

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Technology Process of 2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

There total 1 articles about 2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.5%

: 117997-81-6
5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid

: 75-65-0
tert-butyl alcohol

: 1310037-42-3
2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; dmap; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1310037-42-3
2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

: 1310039-00-9
2-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-1,1-dioxo-1λ6-[1,2]thiazinane-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 2 h / 2327.23 Torr

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -20 °C

2.2: 2 h / Cooling with ice

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h

3.2: 5 h / 20 °C / Cooling with ice

4.1: sodium acetate; acetic acid / water / 0.17 h / Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; di-isopropyl azodicarboxylate; hydrogen; sodium acetate; potassium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1310037-42-3
2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

: 1310039-02-1
2-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-1,1-dioxo-1λ6-[1,2]thiazinane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 2 h / 2327.23 Torr

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -20 °C

2.2: 2 h / Cooling with ice

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h

3.2: 5 h / 20 °C / Cooling with ice

4.1: sodium acetate; acetic acid / water / 0.17 h / Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; di-isopropyl azodicarboxylate; hydrogen; sodium acetate; potassium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;