5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

Base Information

Chemical Name:5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine
CAS No.:1349770-36-0
Molecular Formula:C₂₃H₂₂N₄O₃S
Molecular Weight:434.519
Hs Code.:

Synonyms:5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

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Chemical Property of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

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Technology Process of 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

There total 11 articles about 5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1349770-82-6
tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

: 1349770-36-0
5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

Guidance literature:: tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 905966-34-9
5-bromo-3-(2-(trimethylsilyl)ethynyl)pyridine-2-amine

: 1349770-36-0
5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / dichloromethane / 3 h / 20 °C

2: water; sodium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: triethylamine / tetrahydrofuran / 18 h / 20 - 65 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With dmap; water; potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 13472-79-2
5-iodo-pyridin-2-ol

: 1349770-36-0
5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; copper(l) iodide / isopropyl alcohol; ethylene glycol / 2 h / 120 °C / Microwave irradiation

2: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 1.17 h / 20 - 954 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With copper(l) iodide; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; phosphorus(V) oxybromide; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol;