tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

Base Information

Chemical Name:tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate
CAS No.:1349770-82-6
Molecular Formula:C₃₃H₃₈N₄O₇S
Molecular Weight:634.753
Hs Code.:

Synonyms:tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

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Chemical Property of tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

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Technology Process of tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

There total 9 articles about tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1245648-96-7
2-bromo-5-isopropylsulfonyl-pyridine

: 1349770-79-1
tert-butyl N-tert-butoxycarbonyl-N-[3-[3-(p-tolyl)isoxazol-5-yl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]carbamate

: 1349770-82-6
tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 95 ℃; for 2h; Inert atmosphere;

Reference yield:

: 381233-96-1
2-amino-3-iodo-5-bromopyridine

: 1349770-82-6
tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 3 h / 20 °C

3: water; sodium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4: triethylamine / tetrahydrofuran / 18 h / 20 - 65 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

6: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

With dmap; copper(l) iodide; water; potassium acetate; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 18108-74-2
5-isopropylsulfanylpyridin-2-ol

: 1349770-82-6
tert-butyl N-tert-butoxycarbonyl-N-[5-(5-isopropylsulfonyl-2-pyridyl)-3-[3-(p-tolyl)isoxazol-5-yl]-2-pyridyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 1.17 h / 20 - 954 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 95 °C / Inert atmosphere

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; phosphorus(V) oxybromide; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;