((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

Base Information

Chemical Name:((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester
CAS No.:213964-89-7
Molecular Formula:C₂₀H₂₅NO₃S
Molecular Weight:359.489
Hs Code.:

Synonyms:((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

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Chemical Property of ((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

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Technology Process of ((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

There total 11 articles about ((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 882-33-7
diphenyldisulfane

: 213964-88-6
((2R,4S)-2,5-Dihydroxy-4-methyl-pentyl)-carbamic acid benzyl ester

: 213964-89-7
((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

Guidance literature:: With tributylphosphine; In pyridine; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01284-2

Reference yield:

: 53558-93-3
(R)-tetrahydro-5-oxo-2-furancarboxylic acid

: 213964-89-7
((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: BH₃*SMe₂ / tetrahydrofuran

2: imidazole / dimethylformamide

3: LDA / tetrahydrofuran / -78 °C

4: TBAF / tetrahydrofuran / 1 h / Ambient temperature

5: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

6: NaN₃ / dimethylformamide / 2 h / 90 °C

7: H₂ / Pd/C / tetrahydrofuran / 2 h / Ambient temperature

8: Et₃N / tetrahydrofuran

9: 94 percent / NaBH₄ / methanol; tetrahydrofuran / 0.25 h / 60 °C

10: 74 percent / n-Bu₃P / pyridine / 1 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; sodium azide; tributylphosphine; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01284-2

Reference yield:

: 52813-63-5
(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone

: 213964-89-7
((2R,4S)-2-Hydroxy-4-methyl-5-phenylsulfanyl-pentyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: imidazole / dimethylformamide

2: LDA / tetrahydrofuran / -78 °C

3: TBAF / tetrahydrofuran / 1 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

5: NaN₃ / dimethylformamide / 2 h / 90 °C

6: H₂ / Pd/C / tetrahydrofuran / 2 h / Ambient temperature

7: Et₃N / tetrahydrofuran

8: 94 percent / NaBH₄ / methanol; tetrahydrofuran / 0.25 h / 60 °C

9: 74 percent / n-Bu₃P / pyridine / 1 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; sodium azide; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01284-2