3-(Pyridin-2-YL)[1,2,3]triazolo[1,5-A]pyridine

Base Information

• Chemical Name: 3-(Pyridin-2-YL)[1,2,3]triazolo[1,5-A]pyridine
• CAS No.: 947-88-6
• Molecular Formula: C11H8N4
• Molecular Weight: 196.21
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50447648
• Nikkaji Number: J1.184.201A
• Wikidata: Q82266522
• Mol file: 947-88-6.mol

Synonyms:947-88-6;3-(2-Pyridyl)-1,2,3-triazolo(1,5-a)pyridine;3-(PYRIDIN-2-YL)[1,2,3]TRIAZOLO[1,5-A]PYRIDINE;3-pyridin-2-yltriazolo[1,5-a]pyridine;3-Pyridin-2-yl[1,2,3]triazolo[1,5-a]pyridine;3-(Pyridin-2-yl)-[1,2,3]triazolo[1,5-a]pyridine;2-{[1,2,3]triazolo[1,5-a]pyridin-3-yl}pyridine;SCHEMBL5586475;DTXSID50447648;MFCD08062393;AKOS026675533;PS-6038;SB52654;CS-0458168;FT-0719166;3-(2-Pyridyl)[1,2,3]triazolo[1,5-a]pyridine;3-(2-pyridyl)-[1,2,3]triazolo[1,5-a]-pyridine;[1,2,3]Triazolo[1,5-a]pyridine,3-(2-pyridinyl)-

Chemical Property of 3-(Pyridin-2-YL)[1,2,3]triazolo[1,5-A]pyridine

Chemical Property:

• Refractive Index: 1.717
• PSA: 43.08000
• Density: 1.31 g/cm³
• LogP: 1.79130
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 196.074896272
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

98%Min ^*data from raw suppliers

3-Pyridin-2-yl[1,2,3]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=C3C=CC=CN3N=N2

Technology Process of 3-(Pyridin-2-YL)[1,2,3]triazolo[1,5-A]pyridine

There total 2 articles about 3-(Pyridin-2-YL)[1,2,3]triazolo[1,5-A]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(6-iodopyridin-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (873012-92-1) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → (2S)-3-(4-hydroxyphenyl)-2-{[6-([1,2,3]triazolo[1,5-a]pyridin-3-yl)-pyridin-2-yl]amino}propanoic acid + 3-pyridin-2-yl-[1,2,3]triazolo[1,5-a]pyridine (947-88-6)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl acetamide; at 90 ℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c8nj02725k

Reference yield:

3-(6-iodopyridin-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (873012-92-1) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (2S)-3-phenyl-2-{[6-([1,2,3]triazolo[1,5-a]pyridin-3-yl)pyridin-2-yl]amino}propanoic acid + 3-pyridin-2-yl-[1,2,3]triazolo[1,5-a]pyridine (947-88-6)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl acetamide; at 90 ℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c8nj02725k

Reference yield: 72.0%

3-pyridin-2-yl-[1,2,3]triazolo[1,5-a]pyridine (947-88-6) → bis(2-pyridyl)methane (1132-37-2)

Guidance literature:

With palladium 10% on activated carbon; zinc; In ethanol; at 150 ℃; for 24h; Reagent/catalyst; Autoclave;

DOI:10.3998/ark.5550190.p008.227

upstream raw materials:

3-(6-iodopyridin-2-yl)-[1,2,3]triazolo[1,5-a]pyridine

L-tyrosine

L-phenylalanine

Downstream raw materials:

3-(6'-(di(p-methoxyphenyl)phosphino)pyridin-2'-yl)-[1,2,3]triazolo[1,5-a]pyridine

7-(di(p-methoxyphenyl)phosphino)-3-(pyridin-2'-yl)-[1,2,3]triazolo[1,5-a]pyridine

C₂₅H₂₁N₄O₂PSe

3-(6'-(di(p-trifluoromethylphenyl)phosphino)pyridin-2'-yl)-[1,2,3]triazolo[1,5-a]pyridine