4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

Base Information

Chemical Name:4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone
CAS No.:147056-29-9
Molecular Formula:C₃₀H₃₂N₂O₅
Molecular Weight:500.594
Hs Code.:

Synonyms:4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

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Chemical Property of 4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

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Technology Process of 4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

There total 4 articles about 4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 147056-28-8
4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-3,3-diethyl-2-azetidinone

: 3173-56-6
benzyl isothiocyanate

: 147056-29-9
4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 6h; Heating;
DOI:10.1021/jm00058a015

Reference yield:

: 67853-01-4
benzyl 4-(hydroxymethyl)benzoate

: 147056-29-9
4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) tert-butylmagnesium chloride / 1.) hexanes, THF, 0 deg C, 15 min, 2.) hexanes, THF, RT, 3 h

2: 40 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 6 h / Heating

With dmap; tert-butylmagnesium chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm00058a015

Reference yield:

: 78767-55-2
benzyl 4-formylbenzoate

: 147056-29-9
4-<<4-(benzyloxycarbonyl)phenyl>methoxy>-1-<(benzylamino)carbonyl>-3,3-diethyl-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

2: 1.) tert-butylmagnesium chloride / 1.) hexanes, THF, 0 deg C, 15 min, 2.) hexanes, THF, RT, 3 h

3: 40 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 6 h / Heating

With dmap; sodium tetrahydroborate; tert-butylmagnesium chloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00058a015