1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene

Base Information

• Chemical Name: 1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene
• CAS No.: 406917-31-5
• Molecular Formula: C₂₀H₂₂N₂O₇S
• Molecular Weight: 434.47
• Mol file: 406917-31-5.mol

Synonyms:1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene

Chemical Property of 1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene

There total 2 articles about 1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-toluenesulfonylacetone (5366-49-4) + N,N'-bis(methoxycarbonyl)-p-benzoquinone diimine → 1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene (406917-31-5)

Guidance literature:

With sodium methylate; In 1,4-dioxane; at 20 ℃; for 8h;

DOI:10.1023/A:1012407423432

Reference yield:

sodium 4-methylbenzenesulfinate (824-79-3) → 1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene (406917-31-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / ethanol / 6 h / 70 °C

2: 72 percent / MeONa / dioxane / 8 h / 20 °C

With sodium methylate; In 1,4-dioxane; ethanol;

DOI:10.1023/A:1012407423432

Reference yield: 76.0%

1,4-bis-(methoxycarbonylamino)-2-(2-oxo-1-tosylpropyl)benzene (406917-31-5) → methyl 5-methoxycarbonylamino-3-tosylindole-1-carboxylate

Guidance literature:

With hydrogenchloride; for 1.5h; Heating;

DOI:10.1023/A:1012407423432

upstream raw materials:

4-toluenesulfonylacetone

sodium 4-methylbenzenesulfinate