(±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

Base Information

Chemical Name:(±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate
CAS No.:281195-11-7
Molecular Formula:C₁₇H₂₅NO₅Si
Molecular Weight:351.475
Hs Code.:

Synonyms:(±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

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Chemical Property of (±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

Chemical Property:

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Technology Process of (±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

There total 3 articles about (±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 114106-93-3
methyl 2-[hydroxy(4-nitrophenyl)methyl]prop-2-enoate

: 281195-11-7
(±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

Guidance literature:: With triethylamine;
DOI:10.1016/j.tetlet.2007.10.149

Reference yield: 95.0%

: 114106-93-3
methyl 2-[hydroxy(4-nitrophenyl)methyl]prop-2-enoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 281195-11-7
(±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2006.03.006

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 281195-11-7
(±)-methyl 2-((tert-butyldimethylsilyloxy)(4-nitrophenyl)methyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diazabicyclo[2.2.2]octane / sonication

2: 95 percent / imidazole / dimethylformamide / 8 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; In N,N-dimethyl-formamide; 1: Baylis-Hillman reaction;
DOI:10.1016/j.ejmech.2006.03.006