12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

Base Information

Chemical Name:12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine
CAS No.:154227-80-2
Molecular Formula:C₂₁H₁₅N₃O₂
Molecular Weight:341.369
Hs Code.:

Synonyms:12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

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Chemical Property of 12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

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Technology Process of 12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

There total 2 articles about 12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33265-72-4
1-(2-aminomethylphenyl)-1H-pyrroloe hydrochloride

: 154227-80-2
12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / maleic acid / ethanol / 6 h / Heating

2: 1.) Na / 1.) xylene, 70 deg C, 2.) xylene, reflux, overnight

With sodium; maleic acid; In ethanol;
DOI:10.1002/jhet.5570300409

Reference yield:

: 103-71-9
phenyl isocyanate

: 154227-77-7
5,6-dihydro-4H-pyrrolo<1,2-a><1,4>benzodiazepine-4,4-diacetic acid diethyl ester

: 154227-80-2
12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

Guidance literature:: With sodium; Yield given. Multistep reaction; 1.) xylene, 70 deg C, 2.) xylene, reflux, overnight;
DOI:10.1002/jhet.5570300409

Reference yield: 92.0%

: 154227-80-2
12,13-dihydro-11,13-dioxo-12-phenyl-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

: 11,13-dioxo-12-phenyl-12,13,14,14a-tetrahydro-9H,11H-pyrimido<4,3-c>pyrrolo<1,2-a><1,4>benzodiazepine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 6h; under 2585.7 Torr;
DOI:10.1002/jhet.5570300409