1-[2-(1H-pyrrol-1-yl)phenyl]methanamine hydrochloride

Base Information

• Chemical Name: 1-[2-(1H-pyrrol-1-yl)phenyl]methanamine hydrochloride
• CAS No.: 33265-72-4
• Molecular Formula: C₁₁H₁₂N₂*ClH
• Molecular Weight: 208.691
• Mol file: 33265-72-4.mol

Synonyms:33265-72-4;1-[2-(1H-pyrrol-1-yl)phenyl]methanamine hydrochloride;Benzenemethanamine, 2-(1H-pyrrol-1-yl)-, monohydrochloride;[2-(1-pyrrolyl)phenyl]methanamine hydrochloride;39116-24-0;MFCD22123293;AKOS024396772;2-(Pyrrol-1-yl)benzylamine hydrochloride;(2-pyrrol-1-ylphenyl)methanamine hydrochloride;(2-pyrrol-1-ylphenyl)methanamine;hydrochloride;A824411

Chemical Property of 1-[2-(1H-pyrrol-1-yl)phenyl]methanamine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 208.0767261
• Heavy Atom Count: 14
• Complexity: 152

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CN)N2C=CC=C2.Cl

Technology Process of 1-[2-(1H-pyrrol-1-yl)phenyl]methanamine hydrochloride

There total 3 articles about 1-[2-(1H-pyrrol-1-yl)phenyl]methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-(1H-pyrrol-1-yl)benzonitrile (418762-89-7) → 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt (418762-90-0) + 1-(2-aminomethylphenyl)-1H-pyrroloe hydrochloride (33265-72-4)

Guidance literature:

2-chloro-6-(1H-pyrrol-1-yl)benzonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Cooling with ice; Reflux;

With water; rochelle salt; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 2h; Cooling with ice;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield:

2-amino-6-chlorobenzonitrile (6575-11-7) → 1-(2-aminomethylphenyl)-1H-pyrroloe hydrochloride (33265-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.5 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Reflux

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran;

Reference yield:

2-amino-6-chlorobenzonitrile (6575-11-7) → 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt (418762-90-0) + 1-(2-aminomethylphenyl)-1H-pyrroloe hydrochloride (33265-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 0.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Reflux

2.2: 2 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran;

upstream raw materials:

2-amino-6-chlorobenzonitrile

2-chloro-6-(1H-pyrrol-1-yl)benzonitrile

Downstream raw materials:

C₂₃H₂₅N₃

C₂₂H₂₂N₄O₂

C₂₃H₂₄ClN₃

1-(2-methoxycarbonylacetamidomethyl)phenyl-1H-pyrrole