(R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

Base Information

Chemical Name:(R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide
CAS No.:1312479-66-5
Molecular Formula:C₂₈H₃₉N₃O₇S
Molecular Weight:561.7
Hs Code.:

Synonyms:(R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

There total 10 articles about (R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1312479-66-5
(R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; copper(l) iodide / 2-(N,N-dimethylamino)ethanol / 48 h / 55 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C

3: potassium carbonate / Pd EnCat_.(TM). / 1,4-dioxane; water / 80 °C

With potassium phosphate; copper(l) iodide; potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; 2-(N,N-dimethylamino)ethanol; water;

Reference yield:

: 1312479-65-4
(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)methanol

: 1312478-57-1
(2R)-4-(4-iodo-2-oxopyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1312479-66-5
(R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

Guidance literature:: With potassium carbonate; Pd EnCat; In 1,4-dioxane; water; at 80 ℃;

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 1312479-66-5
(R)-4-{4-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-2-oxo-2H-pyridin-1-yl}-2-methanesulfonyl-2-methyl-N-(tetrahydropyran-2-yloxy)-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; copper(l) iodide / 2-(N,N-dimethylamino)ethanol / 48 h / 55 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C

3: potassium carbonate / Pd EnCat_.(TM). / 1,4-dioxane; water / 80 °C

With potassium phosphate; copper(l) iodide; potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; 2-(N,N-dimethylamino)ethanol; water;