4-IODO-2-PYRIDONE

Base Information

• Chemical Name: 4-IODO-2-PYRIDONE
• CAS No.: 858839-90-4
• Molecular Formula: C5H4 I N O
• Molecular Weight: 220.997
• Hs Code.: 2933399090
• Mol file: 858839-90-4.mol

Synonyms:2-Pyridol,4-iodo- (3CI); 4-Iodopyridin-2(1H)-one

Chemical Property of 4-IODO-2-PYRIDONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 186-188°C
• Refractive Index: 1.682
• Boiling Point: 321.552oC at 760 mmHg
• PKA: 10.76±0.10(Predicted)
• Flash Point: 148.269oC
• PSA: 32.86000
• Density: 2.124g/cm3
• LogP: 0.97950
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4-Iodopyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODO-2-PYRIDONE

There total 3 articles about 4-IODO-2-PYRIDONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-4-iodopyridine (153034-86-7) → 4-iodo-1,2-dihydropyridin-2-one (858839-90-4)

Guidance literature:

With sodium acetate; acetic acid; at 150 ℃; for 72h; Sealed tube;

DOI:10.1055/s-0035-1560469

Reference yield: 60.6%

2-fluoro-4-iodopyridine (22282-70-8) → 4-iodo-1,2-dihydropyridin-2-one (858839-90-4)

Guidance literature:

With acetic acid; In water; at 100 ℃; for 5h;

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) → 4-iodo-1,2-dihydropyridin-2-one (858839-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tert.-butylnitrite / acetonitrile / 16 h / 0 - 20 °C

2: sodium acetate; acetic acid / 72 h / 150 °C / Sealed tube

With copper(l) iodide; tert.-butylnitrite; sodium acetate; acetic acid; In acetonitrile; 1: |Sandmeyer Reaction;

DOI:10.1055/s-0035-1560469

upstream raw materials:

2-chloro-4-iodopyridine

2-fluoro-4-iodopyridine

4-Amino-2-chloropyridine

Downstream raw materials:

(2R)-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(1H-pyrazol-1-yl)phenyl]pyridin-1(2H)-yl}-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

(2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(1H-pyrazol-1-yl)phenyl]pyridin-1(2H)-yl}butanamide

(2R)-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[(E)-2-phenylvinyl]pyridin-1(2H)-yl}-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

(2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[(E)-2-phenylvinyl]pyridin-1(2H)-yl}butanamide

Refernces

• 1、 -. "PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS". Page/Page column 42; 43. . Retrieved 2019/10/04.
• 2、 -. "FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS". Page/Page column 48. . Retrieved 2015/07/16.