5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

Base Information

Chemical Name:5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine
CAS No.:913282-80-1
Molecular Formula:C₁₆H₈Cl₂F₃N₃
Molecular Weight:370.161
Hs Code.:

Synonyms:5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

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Technology Process of 5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

There total 1 articles about 5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 913282-79-8
C₁₆H₁₀ClF₃N₄

: 913282-80-1
5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

Guidance literature:: With hydrogenchloride; copper(l) chloride; sodium nitrite;
DOI:10.1016/j.bmcl.2008.04.022

Reference yield: 85.0%

: 913282-80-1
5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 913277-42-6
C₂₆H₂₇ClF₃N₅O₂

Guidance literature:: With potassium fluoride; 2,4-dichlorophenoxyacetic acid dimethylamine; In dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2008.04.022

Reference yield:

: 913282-80-1
5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine

: 141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate

: 3-[6-(3-chloro-pyridin-4-yl)-5-(4-trifluoromethyl-phenyl)-pyrazin-2-yloxy]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl 3-hydroxyazetidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

5-chloro-3-(3-chloro-pyridin-4-yl)-2-(4-trifluoromethyl-phenyl)-pyrazine; In tetrahydrofuran;