(R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

Base Information

Chemical Name:(R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate
CAS No.:1428470-79-4
Molecular Formula:C₂₅H₃₀O₇
Molecular Weight:442.509
Hs Code.:

Synonyms:(R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

There total 5 articles about (R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1428470-87-4
(R)-tert-butyl 3-[4,5-methylenedioxy-2-(trifluoromethanesulfonyloxy)phenyl]-3-(3,4,5-trimethoxyphenyl)propanoate

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1428470-79-4
(R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride; In N,N-dimethyl-formamide; at 50 ℃; for 7h;
DOI:10.1021/jo400147f

Reference yield:

: 533-31-3
Sesamol

: 1428470-79-4
(R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: zinc trifluoromethanesulfonate / dichloromethane / 9 h / 30 °C

2: samarium diiodide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; water / 1 h / 20 °C

3: pyridine / dichloromethane / -40 - 0 °C

4: lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 7 h / 50 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; zinc trifluoromethanesulfonate; lithium chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4: |Stille Cross Coupling;
DOI:10.1021/jo400147f

Reference yield:

: 1428470-86-3
(R)-tert-butyl 3-(2-hydroxy-4,5-methylenedioxyphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

: 1428470-79-4
(R)-tert-butyl 3-(4,5-methylenedioxy-2-vinylphenyl)-3-(3,4,5-trimethoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / -40 - 0 °C

2: lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 7 h / 50 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 2: |Stille Cross Coupling;
DOI:10.1021/jo400147f