(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

Base Information

Chemical Name:(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate
CAS No.:1445591-98-9
Molecular Formula:C₁₅H₁₅BrN₂O₂
Molecular Weight:335.2
Hs Code.:

Synonyms:(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

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Chemical Property of (1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

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Technology Process of (1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

There total 6 articles about (1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1445590-32-8
(1,2-trans)-1-(2-(4-bromophenyl)-2-oxoethyl) 2-methyl cyclobutane-1,2-dicarboxylate

: 1445591-98-9
(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

Guidance literature:: With ammonium acetate; at 150 - 160 ℃; for 2.5h; Dean-Stark;

Reference yield:

: 4462-96-8
3-oxabicyclo[3.2.0]heptane-2,4-dione

: 1445591-98-9
(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: quinine / toluene; tetrachloromethane / 72 h / -50 °C

2: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -70 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C

4: ammonium acetate / 2.5 h / 150 - 160 °C / Dean-Stark

With ammonium acetate; quinine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; toluene; acetonitrile;

Reference yield:

: 58616-97-0
(1S,2S)-(+)-trans-1,2-cyclobutanedicarboxylic acid

: 1445591-98-9
(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 0 - 20 °C

2: ammonium acetate / 2.5 h / 150 - 160 °C / Dean-Stark

With ammonium acetate; N-ethyl-N,N-diisopropylamine; In acetonitrile;