(R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

Base Information

Chemical Name:(R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate
CAS No.:1357575-59-7
Molecular Formula:C₃₁H₄₈F₃N₄O₈PS₃
Molecular Weight:788.911
Hs Code.:

Synonyms:(R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

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Chemical Property of (R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

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Technology Process of (R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

There total 12 articles about (R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1357575-58-6
di-tert-butyl 2-(piperazin-1-yl)ethyl phosphate

: 1357575-44-0
(R)-4-((4-oxo-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

: 1357575-59-7
(R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

Guidance literature:: di-tert-butyl 2-(piperazin-1-yl)ethyl phosphate; (R)-4-((4-oxo-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide; In 1,2-dichloro-ethane; at 18 - 25 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 18 - 25 ℃; for 1h;

Reference yield:

: 81088-96-2
4-(2-chloroethyl)piperazine-1-carboxylic acid benzyl ester

: 1357575-59-7
(R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 1.67 h / 100 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol

3.1: 1,2-dichloro-ethane / 0.25 h / 18 - 25 °C

3.2: 1 h / 18 - 25 °C

With hydrogen; palladium 10% on activated carbon; In methanol; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1357575-57-5
benzyl 4-(2-(di-tert-butoxyphosphoryloxy)ethyl)piperazine-1-carboxylate

: 1357575-59-7
(R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol

2.1: 1,2-dichloro-ethane / 0.25 h / 18 - 25 °C

2.2: 1 h / 18 - 25 °C

With hydrogen; palladium 10% on activated carbon; In methanol; 1,2-dichloro-ethane;