Technology Process of 4-(2-chloro-pyridin-4-yloxy)-2,3-difluorophenylamine
There total 3 articles about 4-(2-chloro-pyridin-4-yloxy)-2,3-difluorophenylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-amino-2,3-difluoro-phenol;
With
potassium tert-butylate;
In
N,N-dimethyl acetamide;
at 20 ℃;
for 0.5h;
2,4-dichloropyridine;
In
N,N-dimethyl acetamide;
at 85 ℃;
for 4h;
DOI:10.1021/acs.jmedchem.0c02093
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
2.1: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 32 °C
3.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C
3.2: 4 h / 85 °C
With
palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate;
In
methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02093
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 32 °C
2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C
2.2: 4 h / 85 °C
With
palladium 10% on activated carbon; potassium tert-butylate; hydrogen;
In
methanol; N,N-dimethyl acetamide;
DOI:10.1021/acs.jmedchem.0c02093
