6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide

Base Information

• Chemical Name: 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide
• CAS No.: 99082-56-1
• Molecular Formula: C₂₃H₃₀N₂O₄S
• Molecular Weight: 430.568

Synonyms:6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide

Chemical Property of 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide

Chemical Property:

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Technology Process of 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide

There total 1 articles about 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-[bis-(hydroxymethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline (98661-43-9) + phenyl isothiocyanate (103-72-0) → 6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide (99082-56-1)

Guidance literature:

In benzene; for 1h; Heating;

Reference yield: 75.0%

6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide (99082-56-1) → {(4S,4aS)-6,7-Diethoxy-1-[(Z)-phenylimino]-4,4a,9,10-tetrahydro-3H-2-thia-10a-aza-phenanthren-4-yl}-methanol (124482-25-3)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.5h; Heating;

Reference yield:

6,7-Diethoxy-1-(2-hydroxy-1-hydroxymethyl-ethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioic acid phenylamide (99082-56-1) → {(4S,4aS)-6,7-Diethoxy-1-[(Z)-phenylimino]-4,4a,9,10-tetrahydro-3H-2-oxa-10a-aza-phenanthren-4-yl}-methanol (124482-19-5)

Guidance literature:

With potassium hydroxide; methyl iodide; Yield given. Multistep reaction; 1) MeOH, room temp., 3 h, 2) MeOH, 3 h;

upstream raw materials:

1-[bis-(hydroxymethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline

phenyl isothiocyanate

Downstream raw materials:

{(4S,4aS)-6,7-Diethoxy-1-[(Z)-phenylimino]-4,4a,9,10-tetrahydro-3H-2-oxa-10a-aza-phenanthren-4-yl}-methanol

{(4S,4aS)-6,7-Diethoxy-1-[(Z)-phenylimino]-4,4a,9,10-tetrahydro-3H-2-thia-10a-aza-phenanthren-4-yl}-methanol

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