2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

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Chemical Name:2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid
CAS No.:760967-93-9
Molecular Formula:C₃₅H₄₄N₂O₇SSi
Molecular Weight:664.895
Hs Code.:

Synonyms:2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

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Chemical Property of 2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

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Technology Process of 2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

There total 3 articles about 2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 760968-17-0
(2S,3R)-2-Benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxy-propionic acid methyl ester

: 760967-93-9
2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 15h;
DOI:10.1021/ol048974+ DOI:10.1021/jo050896w

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 760967-93-9
2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / 2,6-lutidine / CH₂Cl₂ / 15 h

2: 80 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 15 h

With 2,6-dimethylpyridine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo050896w

Reference yield:

: 464200-92-8
(E)-methyl 3-(1-tosyl-1H-indol-3-yl)acrylate

: 760967-93-9
2-benzyloxycarbonylamino-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3-triisopropylsilanyloxypropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-butyl hypochlorite; sodium hydroxide; K₂OsO₂ / propan-1-ol / 0.08 h

1.2: 69 percent / (DHQD)2AQN / propan-1-ol / 22 h

2.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / 15 h

3.1: 80 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 15 h

With 2,6-dimethylpyridine; lithium hydroxide; sodium hydroxide; tert-butylhypochlorite; In tetrahydrofuran; propan-1-ol; dichloromethane; water;
DOI:10.1021/jo050896w