(E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

Base Information

Chemical Name:(E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester
CAS No.:1025891-46-6
Molecular Formula:C₂₂H₂₄ClNO₂
Molecular Weight:369.891
Hs Code.:

Synonyms:(E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

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Chemical Property of (E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

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Technology Process of (E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

There total 4 articles about (E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4392-24-9
Cinnamyl bromide

: 1067975-40-9
glycine tert-butyl ester, p-chlorobenzaldehyde Schiff base

: 1025891-46-6
(E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

Guidance literature:: Cinnamyl bromide; glycine tert-butyl ester, p-chlorobenzaldehyde Schiff base; (R,R)-3,4,5-trifluorophenyl-3,3'5,5'-tetrahydro-2,6-bis(3,4,5-trifluorophenyl)-4,4'-spiro 4H-di-naphtha[2,1-c:1',2'-e]azepinium bromide; In toluene; at 0 ℃;

With potassium hydroxide; In water; toluene; at 0 ℃; for 2h;

Reference yield:

: 4392-24-9
Cinnamyl bromide

: 1067975-40-9
glycine tert-butyl ester, p-chlorobenzaldehyde Schiff base

: 1025891-46-6
(E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

: (E)-(R)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

Guidance literature:: With potassium hydroxide; chiral binaphthyl-based ammonium salt; In water; toluene; at 0 ℃; for 6h; Title compound not separated from byproducts;
DOI:10.1016/j.tetasy.2006.01.019

Reference yield:

: 6456-74-2
Glycine tert-butyl ester

: 1025891-46-6
(E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / methanol / 20 °C

2: chiral binaphthyl-based ammonium salt; potassium hydroxide / toluene; H₂O / 6 h / 0 °C

With potassium hydroxide; chiral binaphthyl-based ammonium salt; magnesium sulfate; In methanol; water; toluene;
DOI:10.1016/j.tetasy.2006.01.019