4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

Base Information

• Chemical Name: 4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile
• CAS No.: 278183-71-4
• Molecular Formula: C₁₈H₁₈N₂OS
• Molecular Weight: 310.42
• Mol file: 278183-71-4.mol

Synonyms:4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

Chemical Property of 4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

There total 2 articles about 4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(3-Bromo-phenyl)-tetrahydro-pyran-4-carbonitrile (245439-36-5) + 2-amino-benzenethiol (137-07-5) → 4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (278183-71-4)

Guidance literature:

With sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; ethanol; water;

Reference yield:

4-(3-Bromo-phenyl)-tetrahydro-pyran-4-carbonitrile (245439-36-5) + 4-aminotiophenol (1193-02-8) → 4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (278183-71-4)

Guidance literature:

With sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 15h;

Reference yield:

4-[3-(4-Amino-phenyl sulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (278183-71-4) + phenyl chloroformate (1885-14-9) → phenyl(4-{[3-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl]thio}phenyl)carbamate (950204-92-9)

Guidance literature:

With pyridine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 1h;

upstream raw materials:

4-(3-Bromo-phenyl)-tetrahydro-pyran-4-carbonitrile

2-amino-benzenethiol

4-aminotiophenol

Downstream raw materials:

phenyl(4-{[3-(4-cyanotetrahydro-2H-pyran-4-yl)phenyl]thio}phenyl)carbamate