5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

Base Information

Chemical Name:5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester
CAS No.:869584-03-2
Molecular Formula:C₂₅H₃₂O₄
Molecular Weight:396.527
Hs Code.:

Synonyms:5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

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Chemical Property of 5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

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Technology Process of 5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

There total 1 articles about 5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 5-adamantan-1-yl-3-oxopentanoic acid ethyl ester

: 70-11-1
α-bromoacetophenone

: 869584-03-2
5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; for 16h; Heating;
DOI:10.1021/jm0490686

Reference yield: 62.0%

: 869584-03-2
5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

: 869584-06-5
2-adamantan-1-ylethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: With ammonium acetate; acetic acid; at 80 ℃; for 16h;
DOI:10.1021/jm0490686

Reference yield:

: 869584-03-2
5-adamantan-1-yl-3-oxo-2-(2-oxo-2-phenylethyl)pentanoic acid ethyl ester

: 3-{[2-(2-adamantan-1-yl-ethyl)-5-phenyl-1H-pyrrole-3-carbonyl]-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / NH₄OAc; AcOH / 16 h / 80 °C

2: 94 percent / aq. NaOH / ethanol / 16 h / Heating

3: SOCl₂; DMF / CH₂Cl₂ / 0.5 h / 20 °C

4: 157 mg / pyridine / 16 h / 20 °C

5: 93 percent / H₂ / Pd/C / tetrahydrofuran; methanol

With pyridine; sodium hydroxide; thionyl chloride; ammonium acetate; hydrogen; acetic acid; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm0490686