2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

Base Information

Chemical Name:2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine
CAS No.:1333320-16-3
Molecular Formula:C₁₈H₁₇Br₂NO₂
Molecular Weight:439.146
Hs Code.:

Synonyms:2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

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Chemical Property of 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

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Technology Process of 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

There total 5 articles about 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5006-58-6
2,3,5-tribromo-4,6-dimethylpyridine

: 4039-83-2
3-(4-methoxybenzyloxy)propyne

: 1333320-16-3
2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

Guidance literature:: With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo2013669

Reference yield:

: 5407-87-4
2-Amino-4,6-dimethylpyridine

: 1333320-16-3
2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; acetic acid / 1.25 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere; Cooling with ice

2.1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C

3.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; bromine; acetic acid; In tetrahydrofuran; Bromoform; 2.1: Sandmeyer type reaction / 3.1: Sonogashira coupling;
DOI:10.1021/jo2013669

Reference yield:

: 5407-86-3
3,5-dibromo-4,6-dimethylpyridin-2-amine

: 1333320-16-3
2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-3,5-dibromo-4,6-dimethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C

2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; bromine; In tetrahydrofuran; Bromoform; 1: Sandmeyer type reaction / 2: Sonogashira coupling;
DOI:10.1021/jo2013669