4039-83-2

Upstream product

• 107-19-7 propargyl alcohol 
• 824-94-2 p-methoxybenzyl chloride 
• 106-96-7 propargyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 127866-65-3 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole 
• 1262961-64-7 C₁₁H₁₄Br₂O₂ 
• 147298-36-0 1-(((2-bromoallyl)oxy)methyl)-4-methoxybenzene 
• 937184-70-8 2-(4-methoxybenzyloxy)-4-methylquinoline 
• 17988-20-4 (4-methoxy-benzyl)-trimethyl-silane 

Downstream Products

• 162131-80-8 (R)-5,6-epoxy-1-(4-methoxybenzyl)oxy-2-hexyne 
• 161990-29-0 1-(2-Hydroxymethyl-phenyl)-4-(4-methoxy-benzyloxy)-but-2-yn-1-one 
• 207120-89-6 (E)-4-(4-methoxyphenyl)but-3-enal 
• 183559-12-8 (R)-6-(4-Methoxy-benzyloxy)-1-(S)-oxiranyl-hex-4-yn-2-ol 
• 335164-76-6 4-[(4-methoxyphenyl)methoxy]-1-[(2'-bromobiphenyl)-2-yl]-2-butyn-1-ol 
• 335164-58-4 1-(2-bromo-phenyl)-5-(4-methoxy-benzyloxy)-pent-3-yn-2-ol 
• 335164-34-6 1-[(4-methoxyphenyl)methoxy]-7-(phenylseleno)-2-heptyn-4-ol 
• 335164-63-1 1-(8-bromonaphth-1-yl)-4-[(4-methoxyphenyl)methoxy]-2-butyn-1-ol 
• 406720-96-5 (E)-1-(4-methoxybenzyloxy)hept-5-en-2-yn-4-one 
• 207795-41-3 ethyl 4-(4-methoxybenzyloxy)but-2-ynoate 
• 406720-95-4 4-(4-methoxybenzyloxy)-1-phenylbut-2-yn-1-one 
• 406720-91-0 iso-butyl 4-(4-methoxybenzyloxy)but-2-ynoate 
• 406720-97-6 (5E,7E)-1-(4-methoxybenzyloxy)nona-5,7-dien-2-yn-4-one 
• 446262-73-3 (E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene 

Relevant academic research and scientific papers

Enantioselective Palladium-Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides

A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.

3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS

Compounds of formula (I) wherein Het1, Het2, R1, R2 and R3 are as defined in the description. Medicaments.

Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives

Multi-drug resistant tuberculosis (MDR-TB) represents a growing problem for global healthcare systems. In addition to 1.3 million deaths in 2018, the World Health Organisation reported 484,000 new cases of MDR-TB. Isoniazid is a key anti-TB drug that inhibits InhA, a crucial enzyme in the cell wall biosynthesis pathway and identical in Mycobacterium tuberculosis and M. bovis. Isoniazid is a pro-drug which requires activation by the enzyme KatG, mutations in KatG prevent activation and confer INH-resistance. ‘Direct inhibitors’ of InhA are attractive as they would circumvent the main clinically observed resistance mechanisms. A library of new 1,5-triazoles, designed to mimic the structures of both triclosan molecules uniquely bound to InhA have been synthesised. The inhibitory activity of these compounds was evaluated using isolated enzyme assays with 2 (5-chloro-2-(4-(5-(((4-(4-chloro-2-hydroxyphenoxy)benzyl)oxy)methyl)-1H-1,2,3-triazol-1-yl)phenoxy)phenol) exhibiting an IC50 of 5.6 μM. Whole-cell evaluation was also performed, with 11 (5-chloro-2-(4-(5-(((4-(cyclopropylmethoxy)benzyl)oxy)methyl)-1H-1,2,3-triazol-1-yl)phenoxy)phenol) showing the greatest potency, with an MIC99 of 12.9 μM against M. bovis.

An Industrial Perspective on Counter Anions in Gold Catalysis: Underestimated with Respect to “Ligand Effects”

The conversion of a variety of well-known test reactions, representing the key reactivity patterns of gold catalysis, were analyzed by GC and 1H NMR. The study is focused on establishing of a strategical approach for the consideration of ligand

An Industrial Perspective on Counter Anions in Gold Catalysis: On Alternative Counter Anions

A comparison of versatile counter anions was investigated by means of a variety of well-known test reactions representing the key reactivity patterns of homogeneous gold catalysis, the catalytic activity was monitored by GC and 1H NMR. As previ

Cyclopropanation of Benzene Rings by Oxidatively Generated α-Oxo Gold Carbene: One-Pot Access to Tetrahydropyranone-Fused Cycloheptatrienes from Propargyl Benzyl Ethers

Cyclopropanations of benzene rings by oxidatively generated α-oxo gold carbenes are for the first time demonstrated in a Buchner reaction, in which readily available propargyl benzyl ethers are converted in one-pot to tetrahydropyranone-fused cycloheptatrienes via sequential oxidative gold catalysis and base-promoted isomerization. Additional examples of arene cyclopropanations without fragmentation of the cyclopropane ring are also realized. (Figure presented.).

1 - (1 ', 3', 4 ', 6' - Four - O - acetyl - α / β - D - grape pyranose) - 4 - para-substituted aryl - [1, 2, 3] - triazole and its preparation method and application

The invention relates to preparation and application of 1-(1',3',4',6'-tetra-O-acetyl-alpha/beta-D-glucopyanosyl)-4-para-substituted benzyl oxyl methyl-[1,2,3]-triazole serial compounds, wherein the core structure thereof is formed by the substitution of

A synthetic method of the compound animal pen ether class

The invention relates to a synthetic method of a benzyl ether compound. The synthetic method is used for avoiding environmental pollution caused by conventional benzyl ether compound synthetic methods. The synthetic method comprises following steps: step 1, a benzyl silane compound, an oxidizing agent, and a light reaction catalyst are delivered into a reactor, the reactor is vacuumized, and is filled with nitrogen for protection, an alkali compound and an alcohol reagent are delivered into the reactor through syringes, the reactor is exposed to visible light, reaction is carried out at room temperature with magnetic stirring, after reaction, an obtained reaction solution is filtered, and a liquid obtained via filtration is subjected to condensation so as to remove solvents and obtain a concentrated solution; and step 2, the concentrated solution is subjected to silica-gel column chromatography for separation and purification so as to obtain the benzyl ether compound, wherein a mixed solution of petroleum ether and ethyl acetate is taken as an eluent. Reaction conditions are mild; operation is simple and convenient; reaction yield is high; and the maximum reaction yield can be 93%.

Efficient syntheses of climate relevant isoprene nitrates and (1R,5S)-(-)-myrtenol nitrate

Here we report the chemoselective synthesis of several important, climate relevant isoprene nitrates using silver nitrate to mediate a 'halide for nitrate' substitution. Employing readily available starting materials, reagents and Horner-Wadsworth-Emmons chemistry the synthesis of easily separable, synthetically versatile 'key building blocks' (E)- and (Z)-3-methyl-4-chlorobut-2-en-1-ol as well as (E)- and (Z)-1-((2-methyl-4-bromobut-2-enyloxy)methyl)-4-methoxybenzene has been achieved using cheap, 'off the shelf' materials. Exploiting their reactivity we have studied their ability to undergo an 'allylic halide for allylic nitrate' substitution reaction which we demonstrate generates (E)- and (Z)-3-methyl-4-hydroxybut-2-enyl nitrate, and (E)- and (Z)-2-methyl-4-hydroxybut-2-enyl nitrates ('isoprene nitrates') in 66-80% overall yields. Using NOESY experiments the elucidation of the carbon-carbon double bond configuration within the purified isoprene nitrates has been established. Further exemplifying our 'halide for nitrate' substitution chemistry we outline the straightforward transformation of (1R,2S)-(-)-myrtenol bromide into the previously unknown monoterpene nitrate (1R,2S)-(-)-myrtenol nitrate.

Efficient Total Synthesis of Bongkrekic Acid and Apoptosis Inhibitory Activity of Its Analogues

Bongkrekic acid (BKA), isolated from the bacterium Burkholderia cocovenenans, is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis. An efficient total synthesis of BKA has been achieved by employing a three-component convergent strategy based on Kocienski-Julia olefination and Suzuki-Miyaura coupling. It is noteworthy that segment B has been prepared as a new doubly functionalized coupling partner, which contributes to shortening of the number of steps. Torquoselective olefination with an ynolate has also been applied for the efficient construction of an unsaturated ester. Furthermore, it is revealed that 1-methyl-2-azaadamantane N-oxyl is an excellent reagent for final oxidation to afford BKA in high yield. Based on the total synthesis, several BKA analogues were prepared for structure-activity relationship studies, which indicated that the carboxylic acid moieties were essential for the apoptosis inhibitory activity of BKA. More easily available BKA analogues with potent apoptosis inhibitory activity were also developed. Stripped BKA: The highly efficient second-generation total synthesis of bongkrekic acid (BKA), an apoptosis inhibitor, has been developed. The synthesis features a three-component convergent strategy based on a Kocienski-Julia olefination and Suzuki-Miyaura coupling. The structure-activity relationship (SAR) is also examined for the first time (see scheme).