(E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one

Base Information

• Chemical Name: (E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one
• CAS No.: 1373484-59-3
• Molecular Formula: C₂₈H₂₇N₃O₃S
• Molecular Weight: 485.607
• Mol file: 1373484-59-3.mol

Synonyms:(E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one

Chemical Property of (E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one

There total 1 articles about (E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

9-(4-methoxyphenylmethylene)-5-(4-methoxyphenyl)-2-thioxo-2,3,6,7,8,9-hexahydropyrimido[4,5-b]quinolin-4(1H)-one (1027003-74-2) + methyl iodide (74-88-4) → (E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one (1373484-59-3)

Guidance literature:

9-(4-methoxyphenylmethylene)-5-(4-methoxyphenyl)-2-thioxo-2,3,6,7,8,9-hexahydropyrimido[4,5-b]quinolin-4(1H)-one; With metallic base; In ethanol; for 0.5h; Heating;

methyl iodide; In ethanol; at 20 ℃; for 5h; Reflux;

DOI:10.1007/s12272-012-0306-5

Reference yield:

(E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one (1373484-59-3) → 9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-[2-(4-methoxy-phenyl)-4-oxo-thiazolidin-3-yl-amino]-6,7,8,9-tetrahydro-3H-pyrimido[4,5-b]quinolin-4-one (1373484-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 12 h / 20 °C / Reflux

2: ethanol / 6 h / Reflux

3: benzene / Reflux

With hydrazine hydrate; In ethanol; benzene;

DOI:10.1007/s12272-012-0306-5

Reference yield:

(E)-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(methylthio)-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-one (1373484-59-3) → 2-[2-(4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl-amino]-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-6,7,8,9-tetrahydro-3H-pyrimido[4,5-b]quinolin-4-one (1373484-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 12 h / 20 °C / Reflux

2: ethanol / 6 h / Reflux

3: benzene / Reflux

With hydrazine hydrate; In ethanol; benzene;

DOI:10.1007/s12272-012-0306-5

upstream raw materials:

9-(4-methoxyphenylmethylene)-5-(4-methoxyphenyl)-2-thioxo-2,3,6,7,8,9-hexahydropyrimido[4,5-b]quinolin-4(1H)-one

methyl iodide

Downstream raw materials:

9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-(4-oxo-2-phenylthiazolidin-3-yl-amino)-6,7,8,9-tetrahydro-3H-pyrimido[4,5-b]quinolin-4-one

9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-2-[2-(4-methoxy-phenyl)-4-oxo-thiazolidin-3-yl-amino]-6,7,8,9-tetrahydro-3H-pyrimido[4,5-b]quinolin-4-one

2-[2-(4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl-amino]-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-6,7,8,9-tetrahydro-3H-pyrimido[4,5-b]quinolin-4-one

2-[2-(4-chloro-phenyl)-4-oxo-thiazolidin-3-yl-amino]-9-(4-methoxybenzylidene)-5-(4-methoxyphenyl)-3-methyl-6,7,8,9-tetrahydro-3H-pyrimido[4,5-b]quinolin-4-one