N₁-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

Base Information

• Chemical Name: N₁-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride
• CAS No.: 953392-14-8
• Molecular Formula: C₂₂H₂₄FN₃O₅S*ClH
• Molecular Weight: 497.975

Synonyms:N₁-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

Chemical Property of N₁-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

Chemical Property:

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Technology Process of N₁-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

There total 6 articles about N₁-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate (953391-64-5) → N1-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride (953392-14-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

4-bromo-3-fluoro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide (953391-61-2) → N1-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride (953392-14-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 22 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

4-bromo-3-fluorobenzene-1-sulfonyl chloride (351003-51-5) → N1-[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride (953392-14-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0.5 - 2 h / 0 - 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / Heating / reflux

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 18 - 24 h

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 22 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

1,1-dimethylethyl (2-{[3-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate

4-bromo-3-fluorobenzene-1-sulfonyl chloride

4-bromo-3-fluoro-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

3-fluoro-4-(5-methyl-2-furanyl)-N-[2-(methyloxy)-5-nitrophenyl]benzenesulfonamide

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