(3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Base Information

• Chemical Name: (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone
• CAS No.: 887277-67-0
• Molecular Formula: C₂₇H₃₇BrN₄O₅
• Molecular Weight: 577.519

Synonyms:(3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Chemical Property of (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

There total 18 articles about (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(5S,11S,13aR)-5-Benzyl-11-(7-bromo-6-hydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone (887277-66-9) → (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone (887277-67-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/j.bmc.2005.12.063

Reference yield: 75.0%

(-)-(3S,9S,14aR)-9-benzyl-3-(7-chloro-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone (104849-07-2) → (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone (887277-67-0)

Guidance literature:

With lithium bromide; In acetone; for 120h; Inert atmosphere; Darkness;

Reference yield:

N-Cbz-L-Phe (1161-13-3) → (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone (887277-67-0)

Guidance literature:

Multi-step reaction with 10 steps

1: 100 percent / dicyclohexylcarbodiimide; HOBt*H₂O; triethylamine / dimethylformamide / 8 h / 20 °C

2: 86 percent / hydrogen; acetic acid / Pd/C / 12 h

3: 87 percent / dicyclohexylcarbodiimide; HOBt*H₂O; triethylamine / dimethylformamide / 8 h / 20 °C

4: 100 percent / hydrogen; acetic acid / Pd/C / 12 h

5: 94 percent / dicyclohexylcarbodiimide; HOBt*H₂O; triethylamine / dimethylformamide / 8 h / 20 °C

6: 100 percent / 3 h / 0 °C

7: 87 percent / [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium]PF₆; DIEA / dimethylformamide / 3 h

8: 89 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / 20 °C

9: 93 percent / lithium bromide; acetic acid / tetrahydrofuran / 5 h / 20 °C

10: 89 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 25 °C

With hydrogen; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; HATU; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.12.063

upstream raw materials:

(5S,11S,13aR)-5-Benzyl-11-(7-bromo-6-hydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

cyclo(-L-Ae₉-Aib-L-Phe-D-Pro-)

cyclo(-L-Ae₉(epo)-Aib-L-Phe-D-Pro-)

Boc-L-Ae₉-Aib-L-Phe-D-Pro-OtBu

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 887277-67-0 (3S,9S,14aR)-9-benzyl-3-(7-bromo-6-oxoheptyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Send

Send

Metric Ton KG G Pound L ML

Send

Send