(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

Base Information

Chemical Name:(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide
CAS No.:160000-07-7
Molecular Formula:C₂₃H₃₂FNO₃Si
Molecular Weight:417.596
Hs Code.:

Synonyms:(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

Suppliers and Price of (2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

Chemical Property:

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Technology Process of (2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

There total 6 articles about (2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 160000-06-6
(R)-2-Fluoro-2-hydroxymethyl-N-(4-methoxy-phenyl)-3-phenyl-propionamide

: 160000-07-7
(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/0957-4166(94)80050-2

Reference yield:

: (3R)-3-benzyl-3-fluoro-4-hydroxy-1-(p-methoxyphenyl)-2-azetidinone

: 160000-07-7
(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaBH₄ / ethanol / 0.5 h / Ambient temperature

2: 100 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(94)80050-2

Reference yield:

: 160000-02-2
(3R,4S)-3-benzyl-3-fluoro-4-formyl-N-(p-methoxyphenyl)-2-azetidinone

: 160000-07-7
(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-propion-(p-methoxyphenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / KMnO₄, K₂CO₃ / tetrahydrofuran; H₂O / 4 h / Ambient temperature

2: 72 percent / Pb(OAc)4 / dimethylformamide / 2 h / 95 °C

3: 96 percent / aq. NaOH / methanol / 0.5 h / Ambient temperature

4: 95 percent / NaBH₄ / ethanol / 0.5 h / Ambient temperature

5: 100 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; lead(IV) acetate; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; potassium carbonate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(94)80050-2