6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

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Chemical Name:6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine
CAS No.:1398057-16-3
Molecular Formula:C₂₇H₂₄FN₇
Molecular Weight:465.533
Hs Code.:

Synonyms:6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

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Chemical Property of 6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

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Technology Process of 6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

There total 6 articles about 6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1398057-36-7
4-(4-{5-[6-(2-fluoro-phenyl)-pyrido[2,3-b]pyrazin-8-yl]-pyridin-3-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1398057-16-3
6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

Guidance literature:: With formic acid; In water; at 80 ℃; for 4h;

Reference yield:

: 233770-01-9
3-bromo-5-iodopyridine

: 1398057-16-3
6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

3: formic acid / water / 4 h / 80 °C

With formic acid; potassium phosphate tribasic trihydrate; sodium hydrogencarbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1283075-60-4
6,8-dichloropyrido[2,3-b]pyrazine

: 1398057-16-3
6-(2-fluoro-phenyl)-8-{5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-pyridin-3-yl}-pyrido[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

2: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

3: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

4: formic acid / water / 4 h / 80 °C

With formic acid; potassium acetate; sodium hydrogencarbonate; potassium hydrogencarbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;