6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide

Base Information

• Chemical Name: 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide
• CAS No.: 540803-95-0
• Molecular Formula: C₁₉H₁₉NOS
• Molecular Weight: 309.432

Synonyms:6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide

Chemical Property of 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide

Chemical Property:

Purity/Quality:

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Technology Process of 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide

There total 4 articles about 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-phenylhex-5-ynoic acid N-(4-methoxyphenyl)amide (540803-88-1) → 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide (540803-95-0)

Guidance literature:

With Lawessons reagent; In toluene; at 80 ℃; for 4h;

DOI:10.1021/ol0344319

Reference yield:

iodobenzene (591-50-4) → 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide (540803-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / PPh₃; CuI; iPr₂NH / Pd(PhCN)2Cl₂ / toluene / 20 °C

2: 91 percent / EDCI / acetonitrile / 24 h / 20 °C

3: 91 percent / Lawesson's reagent / toluene / 4 h / 80 °C

With Lawessons reagent; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; triphenylphosphine; bis(benzonitrile)palladium(II) dichloride; In toluene; acetonitrile;

DOI:10.1021/ol0344319

Reference yield:

hex-5-ynoic acid (53293-00-8) → 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide (540803-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / PPh₃; CuI; iPr₂NH / Pd(PhCN)2Cl₂ / toluene / 20 °C

2: 91 percent / EDCI / acetonitrile / 24 h / 20 °C

3: 91 percent / Lawesson's reagent / toluene / 4 h / 80 °C

With Lawessons reagent; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; triphenylphosphine; bis(benzonitrile)palladium(II) dichloride; In toluene; acetonitrile;

DOI:10.1021/ol0344319

upstream raw materials:

6-phenylhex-5-ynoic acid N-(4-methoxyphenyl)amide

iodobenzene

hex-5-ynoic acid

6-phenylhex-5-ynoic acid

Downstream raw materials:

7-methoxy-9-phenyl-2,3-dihydro-1H-cyclopentaquinoline

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