cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate

Base Information

• Chemical Name: cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate
• CAS No.: 1221970-77-9
• Molecular Formula: C₃₇H₄₃ClN₆O₆
• Molecular Weight: 703.238

Synonyms:cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate

Chemical Property of cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate

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Technology Process of cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate

There total 1 articles about cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine (911397-54-1) + cyclopentyl N-(tert-butoxycarbonyl)-O-(4-ethynylphenyl)-L-homoserinate (1221970-76-8) → cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate (1221970-77-9)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; for 2h; Reflux;

Reference yield: 65.0%

cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate (1221970-77-9) → cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-L-homoserinate hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate (1221970-77-9) → cyclopentyl O-{4-[(Z)-2-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}vinyl]phenyl}-N-(tert-butoxycarbonyl)-L-homoserinate (1221970-79-1) + cyclopentyl O-[4-(2-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate (1221970-78-0)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In ethanol; dichloromethane; at 80 ℃; for 18h;

upstream raw materials:

4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

cyclopentyl N-(tert-butoxycarbonyl)-O-(4-ethynylphenyl)-L-homoserinate

Downstream raw materials:

cyclopentyl O-{4-[(Z)-2-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}vinyl]phenyl}-N-(tert-butoxycarbonyl)-L-homoserinate

cyclopentyl O-[4-(2-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate

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