4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

• Chemical Name: 4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• CAS No.: 911397-54-1
• Molecular Formula: C10H10N2O3
• Molecular Weight: 443.674
• Hs Code.: 2933990090
• Mol file: 911397-54-1.mol

Synonyms:4-Chloro-5-iodo-7-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine;4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine;

Chemical Property of 4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property:

• PSA: 58.64000
• LogP: 1.10910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 98% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 1 articles about 4-Chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide → 4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine (911397-54-1)

Guidance literature:

With water; zinc(II) chloride; In ethanol; at 80 ℃;

Reference yield: 63.0%

methanol (67-56-1) + 4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine (911397-54-1) + carbon monoxide (201230-82-2) → methyl 2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Guidance literature:

With triethylamine; [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride; at 80 ℃; for 3h; under 5171.62 Torr; Autoclave;

Reference yield: 58.0%

4-chloro-5-iodo-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine (911397-54-1) + cyclopentyl N-(tert-butoxycarbonyl)-O-(4-ethynylphenyl)-L-homoserinate (1221970-76-8) → cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate (1221970-77-9)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; for 2h; Reflux;

Downstream raw materials:

cyclopentyl O-[4-({2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)phenyl]-N-(tert-butoxycarbonyl)-L-homoserinate

C₂₁H₂₀ClN₅O

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