2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate

Base Information

• Chemical Name: 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate
• CAS No.: 1278996-48-7
• Molecular Formula: C₇H₇O₃S*C₆₁H₁₂₀N₃O₈S₃
• Molecular Weight: 1291.03
• Mol file: 1278996-48-7.mol

Synonyms:2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate

Chemical Property of 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate

There total 3 articles about 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

1-O-tosyl-2-O-biotinyl-tetraethylenglycol (1278996-58-9) + 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethylethanamine (1278996-56-7) → 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate (1278996-48-7)

Guidance literature:

In dichloromethane; at 70 ℃; for 168h; under 1500.15 Torr; Inert atmosphere; Pressure vessel;

DOI:10.1016/j.tet.2011.07.089

Reference yield:

rac-2,3-bis(octadecyloxy)propane-1-thiol (144944-51-4,146491-00-1) → 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate (1278996-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PTAD / dichloromethane; acetonitrile / 2.5 h / 20 - 55 °C / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 168 h / 70 °C / 1500.15 Torr / Inert atmosphere; Pressure vessel

With PTAD; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2011.07.089

Reference yield:

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester (77544-60-6) + biotin (58-85-5,22879-79-4) → 2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethyl-N-(2-O-biotinyl-tetraethylenglykol-1-yl)-ethanammonium tosylate (1278996-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 96 h / 20 °C

2: dichloromethane / 168 h / 70 °C / 1500.15 Torr / Inert atmosphere; Pressure vessel

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.tet.2011.07.089

upstream raw materials:

1-O-tosyl-2-O-biotinyl-tetraethylenglycol

2-((2,3-bis(octadecyloxy)propyl)disulfanyl)-N,N-dimethylethanamine

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

biotin