(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

Base Information

Chemical Name:(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid
CAS No.:875151-63-6
Molecular Formula:C₂₃H₂₅F₃N₂O₆S
Molecular Weight:514.523
Hs Code.:

Synonyms:(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

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Chemical Property of (S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

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Technology Process of (S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

There total 7 articles about (S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875151-62-5
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

: 875151-63-6
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; for 2h; under 760.051 Torr;

Reference yield:

: 875151-60-3
(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carboxylic acid

: 875151-63-6
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 17 h / 20 °C

2: caesium carbonate / dimethyl sulfoxide / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 875151-59-0
(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carboxylic acid benzyl ester

: 875151-63-6
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

2: 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 17 h / 20 °C

3: caesium carbonate / dimethyl sulfoxide / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;