(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

Base Information

Chemical Name:(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester
CAS No.:875151-62-5
Molecular Formula:C₃₀H₃₁F₃N₂O₆S
Molecular Weight:604.647
Hs Code.:

Synonyms:(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

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Chemical Property of (S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

Chemical Property:

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Technology Process of (S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

There total 6 articles about (S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875151-61-4
(S)-3-(4-hydroxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

: 74-88-4
methyl iodide

: 875151-62-5
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 875151-59-0
(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carboxylic acid benzyl ester

: 875151-62-5
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

2: 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 17 h / 20 °C

3: caesium carbonate / dimethyl sulfoxide / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 875151-62-5
(S)-3-(4-methoxy-phenyl)-2-{[(S)-1-(3-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

3: 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 17 h / 20 °C

4: caesium carbonate / dimethyl sulfoxide / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;