dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

Base Information

Chemical Name:dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate
CAS No.:871266-67-0
Molecular Formula:C₄₀H₃₆N₆O₉S
Molecular Weight:776.827
Hs Code.:

Synonyms:dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

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Chemical Property of dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

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Technology Process of dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

There total 27 articles about dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-acetic acid

: 6327-59-9,174457-99-9
L-aspartic acid dibenzyl ester hydrochloride

: 871266-67-0
dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

Guidance literature:: [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-acetic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 0 ℃; for 0.5h;

L-aspartic acid dibenzyl ester hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 12h;

Reference yield:

: 61874-04-2
(3-formyl-4-hydroxyphenyl)acetic acid methyl ester

: 871266-67-0
dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 5 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / Reflux

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisopropylamine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

4.1: sodium metabisulfite; oxygen; dichloro bis(acetonitrile) palladium(II) / water; isopropyl alcohol / Reflux

5.1: water; hydrogenchloride / acetic acid / 14 h / 50 °C

6.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 0.5 h / 0 °C

6.2: 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium metabisulfite; dichloro bis(acetonitrile) palladium(II); N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; oxygen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 3,4-diaminobenzamidine monohydrochloride

: 871266-67-0
dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxygen / water; isopropyl alcohol / 19 h / 60 °C

2.1: trifluoroacetic acid / 1.5 h / 20 °C

3.1: pyridine hydrochloride / 180 - 185 °C

4.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 0.5 h / 0 °C

4.2: 12 h / 20 °C

With 4-methyl-morpholine; oxygen; pyridine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In N,N-dimethyl acetamide; water; isopropyl alcohol;